Abstract

LCH is a rare, sporadic, and challenging disease manifested by single or multiorgan involvement. Thyroid enlargement, as the initial manifestation, is mostly presented in the pediatric population, which is resistant to conventional treatments for goiter. The timely diagnosis of LCH is important to prevent undesirable complications. This paper presents an 18-month-old girl with an enlarged thyroid in whom papillary cutaneous lesions were found on the scalp, neck, and diaper area, and solitary punched out lytic lesion of the skull. The definite diagnosis of LCH was made after 1.5 months of the initiation of the first symptom. The patient underwent chemotherapy with acceptable results‎.