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Assesment of legalon on kidney functions and Lipids profile in broiler chickens exposed to Hydrogen Peroxide ‎

Alaa Hashim AlMoula , Ahmed Abdulaali Azeez , Kasim Sakran Abass


Milk thistle (Silymarin) is a worldwide valuable medical plant which has been used for many years in the modern and alternative medicine to treat liver diseases. The current study aimed to evaluate the probable effect of legalon (standard hepatic drug) on improvement the kidney functions, lipids profile and body weight in broiler chickens. Twenty-four Ross commercial broiler of thirty days old male were randomly distributed into four treatments of six birds each. The treatment was continued for 3 weeks as follows: 1st group (control) drinking tap water, 2nd group given 0.5% H2O2, 3rd group 0.5% H2O2 and 6mg/kg legalon, and 4th group 6mg/kg legalon single oral dose once daily. The birds’ weight was measured at the end of each week. At the end of the experiment, the broilers were killed and blood parameters were taken for measuring of total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C, risk index creatinine, and urea. The results indicated that hydrogen peroxide-treatment significantly increased serum total cholesterol, triglycerides, LDL-C, VLDL-C and decreased level of HDL-C, risk index as compared with control at P< 0.05.  Concentration of 6mg legalon had significantly good impact on lipids profile and kidney functions, but did not affect significantly the body weight and better effect was obtained in the last two weeks when legalon was administrated alone‎.

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