Antioxidant activity of medicinal plant compounds and aminoacids for prevention of Alzheimer's disease
Abstract
The chronic progression of neurodegeneration is the main characteristic in the development of Alzheimer's disease. The prevention of brain from the neuronal damage by use of phytocompounds with antioxidant activity is an important therapeutic approach for the delay of the neuronal degeneration. The aim of current work is to summarize the data for types of plant compounds possessing antioxidant potential against Alzheimer's disease. From the results it is obvious that the more important phytocomponents with benefitial effect towards oxydative stress in Alzheimer's disease include: 1) flavonoids: quercetin, epigallocatechin-3-gallate, moringine, magnolol, honokiol, kaempferol, isorhamnetin, myricetine; 2) non-flavonoid compounds: Curcumine, Resveratrol, Caffeinc acid, Ferulic acid, Rosmarinic acid; 3) alkaloids: Arecoline, Caffeine, Galantamine, Huperzine A, Morphine, Nicotine, Piperine. Promising antioxidant effect against Alzheimer's disease exhibit the extracts from the different medicinal plants, such as Acorus calamus L., Angelica sinensis L., Asparagus racemosus L., Azima tetracantha Lam, Berberis aquifolium Pursh, Berberis vulgaris L., Camelia sinensis (L.) Kuntze, Centella asiatica L., Citrus aurantium L., Coffea arabica L., Convolvulus pluricaulis Choisy, Coptis chinensis Franch, Curcuma longa L., Daucus carota L., Eryngium campestre L., Eryngium planum L., Galanthus caucasicus (Baker) Grossh., Galanthus nivalis L., Galanthus woronowii Losinsk, Huperzia serrata (Thumb. ex Murray) Trevis., Glycyrrhiza glabra L. Hydrastis canadensis L., Juglans regia L., Lavanduila angustifolia Mill, Leucojum aestivum L., Lycoris radiata (L’Her.) Herb, Narcissus tazetta L., Morus alba L., Panax notoginseng (Butkill) F.H.Chen, Phyllanthus emblica L., Piper longum L., Piper nigrum L.,Vitis vinifera L., Zingiber officinalis L. Antioxidant effects exert L-Arginine, L-Histidine, L-Isoleucine, L-Serine, L-Tryptophan, L-Tyrosine, L-Cysteine, L-Methionine.
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