S. Divya Teja Banda1, K. Ravi Shankar, T. Jaya Prakash1, Firasat Ali

Abstract

Diabetes is the most widely seen metabolic disorder and it is not only a metabolic disorder but also induce some serious disorder like diabetic retinopathy, neuropathy, nephropathy, cardiovascular damage and cataracts etc. The main objective of the present work is to study the anti-diabetic, anti-hyperlipedimic and anti-oxidant activities “ATH-2K13”which was a poly herbal formulation. There are many methods used to induce the diabetes normally, but among all the methods one of the widely accepted method is chemical method of induction and it is easier to induce the diabetes also. As a part of induction we were choosing Streptozotocin as a diabetic control. The standard drug used in the present work was glibenclamide. The two test doses taken in the present study were 100mg/kg and 200mg/kg. Acute toxicity studies and OGTT tests were conducted before screening as safety evaluation of new formulation. The total duration of the study was 14days after 48 hours of diabetes induction to the rats. Total five groups of containing albino Wistar rats of either sex were taken for the evaluation. After 14 days of study blood was collected and serum was separated for the biochemical evaluation. Body weight and blood glucose levels were checked daily.