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Advanced glycation end product inhibitory assay- ‘Achyranthes Aspera leaf’

Sankavi Mahendran, Lakshmi Thangavelu, Anitha Roy


Introduction: Achyranthes aspera leaf is a species of plant in the Amaranthaceae family. It is used as an Ayurvedic herb to make a special medicine that is used extensively in surgical procedures to treat fistula, and as oral medicine for obesity, tumours etc. Materials and Methods: Advanced glycation end products (AGEs) are formed by non-enzymatic glycosylation of proteins that enhance vascular permeability in both micro and macro vascular structures by binding to specific macrophage receptors. The formulation was evaluated for its activity on AGEs formation. Amino guanidine was used as positive control. The percentage activity was calculated with respect to solvent control. Result: AGEs accumulation in body tissues has been implicated in the pathogenesis of diabetes associated complications which is attributed to the formation of free radicals via auto oxidation of glucose and glycated proteins. In our study, Achyranthes has potentially inhibited the AGEs formation with an IC50 of 61.06μg/mL relative to standard amino guanidine which showed IC50 of 72.66µg/ml. Conclusion: According to the results obtained, we know that Achyranthes had potentially inhibited the AGEs formation and it can be used in the synthesis of drugs for diabetic patients. AGEs play an important role in the pathogenesis of diabetic complications during long standing hyperglycaemia state in diabetes mellitus protein glycation and formation of advanced glycation end products.

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