Abstract

Introduction: We investigated the effects of adding bone marrow aspirate to bioglass in repair of rabbit calvarial bone defects. Methods: In this experiment 4 defects were created in each calvarium of the 9 rabbits, and each calvarium defect separately treated by autologous bone marrow mixed with bioglass, bioglass, autologous cancellous bone, and the fourth defect remained without treatment as control. Radiological, histological and histomorphological healing process assessed 4, 8 and 12 weeks postoperatively. Results: Cancellous bone treatment showed the best results radiographically and histologically. Control group showed the lower numbers. Bioglass and bioglass-bone marrow treatments were not enough effective as the cancellous bone treatment during the experiment time line. Conclusion: Although combination of bioglass and autologous bone marrow has a better osteoinductive and osteoconductive properties than bioglass by itself, but in comparison with autogenous cancellous bone, it still has a weaker and poorer osteoinductive and osteoconductive properties.