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Acute and sub-chronic toxicity study of Musa paradisiaca leaf extracts in mice


Sumita Bera , Sanjib Bhattacharya , J. N. Pandey , Moulisha Biswas

Abstract

In the present study, the safety profile of Musa paradisiaca (L.) (Musaceae) leaf was evaluated by acute and sub-chronic toxicity study of the petroleum ether, ethyl acetate and methanol extracts of M. paradisiaca leaf in Swiss albino mice. In acute toxicity study, each extract up to 2000 mg/kg body weight orally did not produce any toxic effect or death. In sub-chronic toxicity study, the three extracts were administered at the single daily dose of 200 mg/kg body weight orally for 28 consecutive days and at the 29th day, different biochemical parameters were evaluated by sacrificing the animals. No mortality was observed during the course of whole study period. No detectable alterations were found in observed biochemical parameters in treated groups when compared to vehicle control group after 28 days. The results of the present study therefore indicated that M. paradisiaca leaf is safe in adult male albino mice demonstrating no noticeable toxicity.




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