× Copyright Disclaimer Privacy Policy Author Guidelines Current Issue Archive Publishing Ethics Join As Reviewer Advertise Submit Article Abstracting And Indexing Editorial Board Contact Editor-in-Chief Scope of the Journal About the Journal

JAPER is indexed in SCOPUS

Acute and sub-chronic toxicity study of Cocos nucifera leaf extracts in mice

Nirankush Paul, Rajarshi Roy, Sanjib Bhattacharya, Moulisha Biswas


In the present study, the safety profile of Cocos nucifera L. (Arecaceae) leaf was evaluated by acute and sub-chronic toxicity study of the petroleum ether, chloroform and methanol extracts of C. nucifera leaf in Swiss albino mice. In acute toxicity study, each extract up to 2000 mg/kg body weight orally did not produce any toxic effect or death. In sub-chronic toxicity study, the three extracts were administered at the single daily dose of 200 mg/kg body weight orally for 28 consecutive days and at the 29th day, the hematological, histological, serum and hepatic biochemical parameters were evaluated by sacrificing the animals. No mortality was observed during the course of whole study period. No detectable alterations were found in hematological, biochemical and histological parameters in treated groups when compared to vehicle control group after 28 days. The results of the present study therefore indicated that C. nucifera leaf is safe in adult male albino mice demonstrating no noticeable toxicity.

Contact SPER Publications

SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India