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Ramin Atighi , Sourena Nazarbaghi , Rahim Zahedi , Rezvan Nourozzadeh

Abstract

Distal Symmetric neuropathy or diabetic neuropathy is the most common complication of diabetes and a significant cause of disability approximately 15 to 20 percent of patients have painful symptoms that can impair their function and quality of life and cause-related disabilities. This study's aim was to compare Venlafaxine with Gabapentin in reducing pain in patients with neuropathic diabetic pain and pain intensity reduction in both groups. The present study was a clinical trial. In this study, 60 patients were studied. Pain intensity in patients was estimated before treatment and eight weeks after treatment using VAS, which was given a score of one to ten, depending on the pain. The differences between the two groups in response to treatment were compared using statistical tests. Rate of pain reduction in both groups before and after treatment with Venlafaxine and Gabapentin was statistically significant (P <0.001).

The severity of initial and post-treatment pain in our study was significantly higher in the Gabapentin-treated group than in the Venlafaxine group (P <0.05). . Rate of pain reduction in both groups before and after treatment with Venlafaxine and Gabapentin was statistically significant (P <0.001) The results of our study, like many previous studies, showed that venlafaxine could be used as an effective drug for treating diabetic neuropathic pain. Results of this study also showed that the effect of Venlafaxine and Gabapentin in the reduction of pain intensity score is the same, and these two drugs are not superior to each other‎.