Abstract

According to recent studies, gene mutations can change the function of insulin and its receptors, so this change can lead to gestational diabetes. Unlike single-gene diseases, getting sick from the mutation allele is affected in a genetic position. Diseases such as type 2 diabetes depend on several gene positions that have a small to medium effect. Arg972 polymorphism in the 1 IRS gene has been shown in diabetic pregnant women or women with gestational hyperglycemia, as well as their infants and its evaluation and association with genetic toxicity in pregnant women. In this study, the frequency of polymorphisms among 50 pregnant women with gestational diabetes was assessed as the patient group and 10 pregnant women without diabetic disorder or pre-diabetes as the control group. Genome DNA was extracted by the kit method and PCR, and sequencing techniques were used to determine individuals' genotypes. The frequency of GG, T / GC, and IRS-1 polymorphism (rs1801278) genotypes was 72% and 28% in the patient group, and 90% and 10% in the control group, respectively.