Mohamad Nadi Sakhvidi, Fatemeh Hosseini, Samaneh Mahmoudi

Abstract

Introduction: 10 to 20 percent of the population and about half of outpatient and hospitalized ‎patients suffer from personality disorder. Drug therapy is one of the effective therapies for ‎personality disorders. The objective of this study was to evaluate the relationship between the ‎use of drugs and personality factors, which could be helpful in the use of more effective drugs ‎in the treatment of personality disorders. This study evaluated the effect of bupropion, a ‎widely-used drug in treatment of depression, on personality factors‏. Methodology: This is a randomized clinical trial study conducted on patients with major ‎depression who referred to medical University Clinics in Yazd. A total of 30 depressed patients ‎were included in this research. Then, they received Beck Inventory and 125 TCI test. The ‎patients were followed-up in the clinic after 6 weeks of treatment. After being interviewed and ‎examined by a psychiatrist, the patients received the TCI and Beck tests again. Finally, the ‎results of each subject were submitted to the statistics consultant to analyze the data.‎ Results: Based on Paired Sample Test and p-value test, there is a significant difference between ‎the mean scores of Beck before and after the treatment and bupropion. In addition, the ‎difference between mean scores of factors of novelty-seeking and reward dependence and self-‎directedness, cooperativeness, and self-transcendence before and after the treatment and ‎bupropion are significant‏. Conclusion: Based on this study, treatment of depression with bupropion causes changes in ‎personality factors. The results of this research can be helpful in treatment of patients with ‎personality disorders. However, further investigations are required to examine the effects of ‎other psychotropic drugs on the treatment of personality disorders, such as antipsychotics and ‎other antidepressants.