Abstract

Introduction: Diabetes is one of the most common diseases in the world. Its prevalence is estimated to be 5% in Iran and it is increasing by rate of 1% per year. It is diagnosable by FBS and HbA1C tests. Objective: The objective of this study was to evaluate the relationship between HbA1C fluctuations and level of interferon gamma and Hs CRP in diabetic patients. Methodology: the research was conducted in the form of case and control, in which case group included 45 diabetic patients whose HbA1C levels were more than 6 AU / ML and 45 healthy subjects were selected as control group. Blood samples were taken from all subjects and HbA1C and interferon-gamma tests were performed using the ELISA method according to the kit's guidelines. Results: Mean HbA1C was 8.8 AU/ML and 5.5 AU/ML in case group and control group, respectively.  IFN Gamma level in subjects of case group was about 84.7% more than normal level.  Conclusion: According to the obtained data, the mean serum level of IFN-γ was more in diabetic patients with HbA1C than that in the normal people, and this difference was statistically significant.