Abstract

Introduction: Patients with multiple sclerosis have high levels of depression and anxiety that this need for intervention counseling, treatment and education targeted in these patients is necessary. This study aimed to evaluate the effectiveness of interventions for the treatment of depression in patients with multiple sclerosis took place. Methods: Electronic search of information using key words multiple sclerosis, depression and psychiatric interventions were. The databases were Iranian Medical Science Database [Iran Medex ], Pub Med, Mag Iran Scientific Database [SID ], Scopus. The search of the above mentioned database was carried out from July to September 1998. Results: 49 studies aimed to evaluate the effect of interventions in the treatment of depression in patients with MS. Finally, the interventions were classified into 6 areas. Interventions were, respectively, from the most used to the least applicable in the following areas: Cognitive-behavioral interventions, exercise and relaxation, education, group therapy, model-based interventions and psychological models, drug interventions. Conclusion: The results of studies indicate that interventions have a positive effect on reducing depression in patients with multiple sclerosis, but more attention is paid to the less costly and accessible interventions based on education and family-based research‎.