Abstract

Background: Prolonged QT interval is one the side effects of atypical antipsychotic medications the aim of this study is assessment of changes in QT interval induced by atypical antipsychotic medications used by patients hospitalized in the psychiatric ward of golestan hospital in 2016. methods: this Retrospective cohort study was conducted on patients admitted to the psychiatric ward of Ahvaz Golestan Hospital in 2016 for 14 months. 105 patients were divided into three 35-member groups receiving Olanzapine, respiridone, and quetiapine. The patients were subjected to ECG assessment at the time of admission and one month after the onset of the treatment. The Qt Prolongation was measured based on Qt interval and the existing relevant criteria. Finally, the Data were analyzed using SPSS software version 22. Results: patients' age was 26.74 ±3.56 in the olanzapine group, 27.43 ±4.62 for the Resperidone group and 26.4 and 1.5 for the Quetiapine group, which was not statistically significant (p-value: 0.434). The mean of the medications dosages administered to the patients during the first month of treatment were 25.55 ±0.94 for the Olanzapine group, 5.28±0.23 for the Resperidone group and 396.57 ±78.78 for the Quetiapine group respectively. The mean of QT interval variations were 448.80 and 6.82 In the Olanzapine group, 452.77 and 18.36, In the Resperidone group, and 447.31 and 10.86 in the Quetiapine group respectively which showed statistically significant differences between the groups (p <0.001). Conclusion: compared with the Olanzapine and quetiapine, Resperidone proved have a more significant impact on QT interval variations.