Abstract

Background: Insulin resistance is a pathophysiological condition in which cells fail to respond normally to insulin. Many studies suggest that amounts of adipose tissue are of the most important risk factors for insulin resistance, also the aging process is usually associated with insulin resistance. Objectives: we decided to perform a study for evaluating these risk factors for insulin resistance in Iranian population. Methods: in cross-sectional study on 1500 Tehran’s population, demographic data including age, gender, and menopausal status, blood samples with 12 hours fasting condition, weight, height, wrist circumference, hip and waist collected and recorded by trained person. All the statistical analysis carried out in SPSS and P-value <0.05 considered statistically significant. Results: Out of 1500 participants, 930 (62%) persons were female and 570 (38%) were male. The main variables in our study (age and body adiposity) in men and women correlated significantly with fasting insulin, least correlation was seen for 2h glucose. After using linear regression model, we show that BMI is not related to metabolic variables but body adiposity has strongest association to all metabolic variables. Age has only related to Fasting Blood sugar (FBS) and 2h insulin. Conclusion: The results of our study show that the amounts of body fat, gender and age affect insulin resistance and BMI except fasting insulin does not have a relationship with other variables.