Assessment of the correlation between Plasma level of Chemerin and inflammatory markers in end-stage renal disease patients undergoing Hemodialysis
Background of the study: One of the major complications of renal failure is inflammation. It is revealed that inflammatory milieu in uremic patients correlates with the increased risk of cardiovascular mortality, anemia, and bone diseases. Therefore, finding any marker with precise prognostic or diagnostic value can have valuable clinical impacts. This study was conducted to investigate the correlation between chemerin levels and inflammatory markers as the indicators of inflammation. Material and methodology: This was a cross-sectional study. Sixty-two hemodialysis patients from 2 hemodialysis centers who aged more than 18 years old enrolled in this study. Linear logistic regression analysis was used to test the correlation between serum phosphate, hs-CRP, and TNF-alpha with chemerin. A comparison between the mean value of groups in different cut-off points of phosphorus with chemerin was performed with an independent sample t-test. Results: There was a direct correlation between chemerin level and hs-CRP (P= 0.013), without any correlation between chemerin and TNF-alpha (P=0.058). Also, there was a direct correlation between hyperphosphatemia and chemerin levels when phosphorus increased to more than 6.5 mg/dl (P=0.039) and more than 7 mg/dl (P=0.001). Conclusion: The current study`s data revealed that the plasma level of chemerin directly correlated with inflammation. Therefore, this adipokine can be proposed as a valuable diagnostic and prognostic tool with clinical impact in hemodialysis patients.
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