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UV Spectrophotometric method for the estimation of nebivolol HCL in bulk and pharmaceutical formulations


Shinkar Dattatraya Manohar , Dhake Avinash Sridhar , Setty Chitral Mallikarjuna

Abstract

In this study, a simple, sensitive and highly accurate ultraviolet pectrophotometric method has been developed and validated for determination of nebivolol hydrochloride in bulk and pharmaceutical formulations. The method is based on the measurement of the absorbance of nebivolol hydrochloride solution in methanol: phosphate buffer pH 6.8 (10:90) at 282 nm in the wavelength range of 200 - 400 nm. Beer’s law was obeyed in the concentration range of 10-50 μg/mL. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery shows that the method was not affected by the presence of common excipients in tablets. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification which proves suitability of proposed method for routine estimation of nebivolol HCL in bulk and pharmaceutical formulations.



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