Study of Agomelatine for the Reduction of Marble Buying Behavior in Brain Disorder
Obsessive-Compulsive Disorder (OCD) is a debilitating disease which is characterized by persistent thoughts (obsessions), which are associated with seemingly purposeful ritualistic behavior (compulsions). The effect of acute and chronic administration of agomelatine on the marble-burying behavior (MBB) of mice, which is reported to be an index of anticompulsive behavior, was performed. Results indicated a potent and dose dependent influence of agomelatine on MBB of mice, which was maintained after its chronic administration. However, the higher doses (40 and 50 mg/kg) were found to be locomotor depressant. Treatment with PCPA was not able to inhibit the effect of agomelatine on marble-burying behavior. In conclusion, agomelatine administration reduces the MBB in mice, which should be explored for its potential use in the treatment of OCD.
Contact SPER Publications
SPER Publications and Solutions Pvt. Ltd.
HD - 236,
Near The Shri Ram Millenium School,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India