× About the Journal Scope of the Journal Contact Editor-in-Chief Editorial Board Current Issue Archive Abstracting And Indexing Submit Article Advertise Join As Reviewer Publishing Ethics

JAPER is indexed in SCOPUS

SCL11A1 Gene Polymorphism and susceptibility to Cutaneous Leishmaniasis in Al-Najaf province-Iraq

Luma H. Ali , Saleem Khuteer Al-Hadraawy


In many regions of Iraq, cutaneous leishmaniasis (CL) is endemic and the number of patients has been increased during the last 10 years. SLC1A11 gene (Solute Carrier family A 11 member 1 protein), formerly called NRAMP1 (Natural Resistance-Associated Macrophage Protein 1 gene) has an essential role in susceptibility to CL and the disease pathology. This study was aimed to investigate the polymorphisms of SLC1A11 gene and detect a relationship between gene variants and susceptibility to CL infection in Iraqi population/AL-Najaf province. The blood samples were collected from (60) patients with CL and (30) apparently healthy controls. Polymorphism of SLC1A11 575-18G/A was detected in control and patients groups by PCR-RFLP technique. The results were as follows: There was not any significant frequency (p=0.67) in the genetic variations of patients and controls; the frequency of allele G in controls was more than the patients, and the genetic variations of 575-18 G/A are not associated with susceptibility to CL infection.

Contact SPER Publications

SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India