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Immunosuppressive effect of Eupalitin-3-O-?-D-Galactoside in Conconavalin-A induced KOI CARP (Cyprinus Carpio).


K. A. Fathima , C. S. Parameswari

Abstract

Eupalitin-3-O-β-D-galactoside a bioflavonoid isolated from Boerhaavia diffusa has been reported to possess immunosuppressive activity.To investigate the potential therapeutic effect of Eupalitin-3-O-β-D-galactoside,Koi carp a fish model was induced with Conconavalin-A and Eupalitin-3-O-β-D-galactoside was injected intramuscularly 48 hrs after Conconavalin-A administration.The results revealed that Eupalitin-3-O-β-D-galactoside attenuated the activity of serum lysozyme and myeloperoxidase in serum and expression of TNF-α expression in head kidney tissues of koi carp.Western blotting results revealed that NFkB and p38 MAPK expression were downregulated after Eupalitin-3-O-β-D-galactoside treatment.These results suggested the anti-inflammatory effect of Eupalitin-3-O-β-D-galactoside in Conconavalin-A induced koi carp possibly through inhibition of NFkB and p38 MAPK that mediates the expression of pro inflammatory cytokine TNF-α.



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