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Formulation Development and Evaluation of Aceclofenac Chitosan Microspheres


Bhavya Rastogi , Amit Chaudhary , Upendra Nagaich

Abstract

Microspheres are matrix systems that contains drug throughout their structure and are potential candidates for oral controlled release. Microsphere can be defined as solid spherical particles ranging from one to 1000 μm in size. Mucoadhesive microspheres provide a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and improve or better therapeutic response of the drug. The effect of chitosan concentration was evaluated with respect to entrapment efficiency, particle size, surface characteristics and in vitro release behaviours. The mean particle size and entrapment efficiency were found to be varied by changing various formulation parameters. The in vitro release profile could be altered significantly by changing various formulation parameters to give a sustained release of drug from the microspheres. Acelofenac loaded chitosan microspheres has shown promising results for a sustained release during an enhanced time duration.



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