S. Ramachandran, Rajani, A. S. Sanjay, M. D. Dhanaraju

Abstract

The present study was aimed to explore the pharmacodynamic interaction of soya milk with atorvastatin. It is food – drug interaction .Wister albino rats of either sex (150-200g) were induced hyperlipidemia by administering triton at dose of 100 mg/kg orallyand they were divided into six groups, each consisting of six each. Normal control group (1) is treated with 1%w/v of carboxy methyl cellulose suspension. Group 2 served as disease control. Group 3 was maintained as standard and was administered with atorvastatin (10mg/kg) orally.To the dyslipidemic 4th, 5th, groupwere administered with soya milk and atorvastatin orally at different doses for 5 weeks respectively. Group 6 receives only soya milk. On the last day blood samples were collected, from all the groups andserum was isolated and subjected to tri glycerides, total cholesterol, and low density lipoproteins and high density lipo protein estimation. Body weight was also calculated. Atorvastatin reduced the serum cholesterol levels in dyslipidemic rats. Whereas combination of atorvastatin with soya milk significantly reduced a lipid level when compared to atorvastatin alone. The combination of atorvastatin with soya milk enhanced the hypolipidaemic activity and is reported as beneficial drug interaction.