× About the Journal Scope of the Journal Contact Editor-in-Chief Editorial Board Current Issue Archives Abstracting And Indexing Submit Article Advertise Join As Reviewer Publishing Ethics


JAPER is indexed in SCOPUS

Effect of novel inhibitor of protein tyrosine phosphatase PTP 1B (NCE-9) on the amelioration of hyperglycemia in DIO mice


Chandrashekhar L Athare , Chandrashekhar D Upasani

Abstract

Metabolic syndrome and type 2 diabetes are complex disorders that are associated with obesity, aging, and genetic predisposition. The increasing prevalence of metabolic abnormalities worldwide presents a serious public health problem, with rates of obesity and diabetes reaching unprecedented levels. A common feature of these disorders is the development of insulin resistance, resulting in decreased insulin-stimulated glucose uptake, failure to suppress hepatic glucose production, and accumulation of hepatic lipid. Recent studies in mice have shown that deficiency of the non-receptor protein tyrosine phosphatase, PTP1B, in liver leads to a host of improvements in metabolic parameters, including improved hepatic insulin sensitivity, reduced liver triglycerides, lower serum and hepatic cholesterol levels, and protection against high-fat diet induced endoplasmic reticulum (ER) stress. Based on these promising studies, PTP1B inhibitors may prove to be a valuable therapeutic tool in the fight against metabolic syndrome and its associated comorbidities. In this study, we investigate effect of NCE-9 in diet induced obese (DIO) mice. NCE-9 significantly improved hyperglycemia and insulin resistance in DIO mice when orally administered at a dose of 30 and 100 mg/kg/day for 28 days. Overall, these studies suggest that NCE-9 improves insulin sensitivity and improves glucose tolerance in animal models through inhibition of PTP1B and that it would be a new therapeutic candidate with potential for the treatment of type 2 diabetic patients.



DOWNLOAD


Contact SPER Publications


SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India