× About the Journal Scope of the Journal Contact Editor-in-Chief Editorial Board Current Issue Archives Abstracting And Indexing Submit Article Advertise Join As Reviewer Publishing Ethics

JAPER is indexed in SCOPUS

Association between DOTS program and the outcome of previous therapy in MDR-TB patients: a case study in Tasikmalaya district, West Java, Indonesia

Mira Miratul Jannah , Ivan S. Pradipta , Prayudi Santoso , Irma M. Puspitasari


Background: Multi-Drug Resistant Tuberculosis (MDR-TB) had been the major health problem in Indonesia. The Directly Observed Treatment Shortcourse (DOTS) is the internationally recommended strategy for TB control that has been recognized as a highly efficient and cost-effective strategy. Tasikmalaya district is one of the districts in West Java with a high prevalence of TB. The aim of this study was to determine the association between DOTS and the failure of previous therapies in MDR-TB patients from Tasikmalaya district. Methods: This study was a preliminary study in analyzing risk factors of MDR-TB in West Java. The patient data was obtained from medical records in January 2015-March 2018 from major TB referral hospitals. All subjects included in this study were adult patients confirmed with MDR-TB with GeneXpert test from Tasikmalaya district and had complete data. Chi-square analysis was performed to determine the association. Results: The total number of subjects included in this study was 31 patients comprised of 19 male (61.3%) and 12 female (38.7%). Twenty subjects (64.5%) received their previous treatment in the DOTS program, and 11 subjects (35.5%) received their treatment in a non-DOTS program. The proportion of outcome (failure and non-failure) of previous therapy was 74.2% to 25.8% ; respectively. The result revealed that the association between the DOTS program and the outcome of previous therapy in MDR-TB was not significant (P=0.251). Conclusion: Although this study had limitations, it showed that there was no association between the DOTS program and the outcome of previous therapy in MDR-TB patients in the Tasikmalaya district.


Contact SPER Publications

SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India