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Antileishmanial effect of Ixora coccinea leaf extracts on the in vitro growth of Leishmania donovani promastigotes


Madhuriya Naskar , Sanjib Bhattacharya , Moulisha Biswas

Abstract

The objective of the present study was to evaluate in vitro antileishmanial activity of leaves form Ixora coccinea L. (Rubiaceae). In the present study, the in vitro antileishmanial activity of ethyl acetate and methanol extracts from I. coccinea leaf was evaluated against Leishmania donovani (strain AG 83) promastigotes by in vitro promastigote cell toxicity assay by using MTT [3-(4,5-dimethylthiazol-2- yl)-2,5 diphenyltetrazolium bromide]. Here, both the extracts markedly inhibited the growth of L. donovani promastigotes in vitro in a concentration dependent manner. The methanol extract was the most active followed by ethyl acetate extract. Therefore, from the present study it can be inferred that I. coccinea leaf exhibited remarkable antileishmanial activity against Leishmania donovani promastigotes in vitro.



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