× About the Journal Scope of the Journal Contact Editor-in-Chief Editorial Board Current Issue Archive Abstracting And Indexing Submit Article Advertise Join As Reviewer Publishing Ethics

JAPER is indexed in SCOPUS

Anti-cytokine and anti-hyperalgesic effects of aliskiren in experimental models of inflammation

Rakesh B. Patel , Kanaiyalal D. Prajapati , Bhavin M. Sonara , Manoranjan M. Sharma , Vishwanath D. Pawar , Mukul R. Jain


The renin‐angiotensin system is involved in pathogenesis and progression of inflammatory responses. In present study, we investigated the anti-cytokine and anti-hyperalgesic potential of aliskiren in LPS (lipopolysaccharide) and CFA (complete Freund’s adjuvant) induced inflammation in rodents. After aliskiren treatment, plasma cytokines (TNF-, IL-6) and plasma renin activity (PRA) were estimated in LPS treated mice. In CFA induced inflammatory pain model, rats were treated with aliskiren and thermal hyperalgesia was evaluated and TNF- and IL-6 were estimated in paw. In LPS treated ICR mice, elevated TNF- and IL-6 levels and PRA were attenuated by aliskiren. In LPS treated double transgenic mice (dTG), harboring human renin and human angiotensinogen and C57BL/6J mice, elevated TNF- level was inhibited by aliskiren. Moreover after LPS treatment, TNF- level was high (2.16 fold) in dTG mice than C57BL/6J. These data indicates that renin overexpression system in dTG mice is responsible for higher TNF- level suggests role of renin in inflammation. Moreover, Aliskiren showed anti-hyperalgesic activity in CFA induced inflammatory hyperalgesia in rats, which might be due to inhibition TNF- and IL- 6 levels, suggests the role of local renin in inflammation. Our results indicate the role of renin in experimental inflammation which is inhibited by aliskiren.

Contact SPER Publications

SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India