Sri Rahayu Evrilia1, Ahmad Muhtadi, Melisa I. Barliana, Rina Winarni

Abstract

The use of rational antibiotic Ceftriaxone in surgery requires paying attention to factors such as antimi-crobial activity at the wound location and the duration of administration because Ceftriaxone includes broad-spectrum antibiotics. An antimicrobial stewardship program aimed to measure the use of antibiotics in hospitals using the average daily dose calculations (DDD). This research aimed to know the differences of DDD values of antibiotic Ceftriaxone before and after the program in surgical patients. This study was an observational analytic study using retrospective analysis of surgical inpatients from December 2015-July 2016. The study involved 197 subjects consisting of 98 subjects before the program, and 99 subjects after the program. The value of DDD /100 patient-day Ceftriaxone antibiotics after the antimicrobial stewardship program was lower than before the program (consecutively 71,194 and 72,692 DDD/100 patient-day, p= 0,001). The use of antibiotics Ceftriaxone was decreased in neurosurgery in digestive patients after an antimicrobial stewardship program.