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Acute and sub-chronic toxicity study of Cocos nucifera leaf extracts in mice


Nirankush Paul , Rajarshi Roy , Sanjib Bhattacharya , Moulisha Biswas

Abstract

In the present study, the safety profile of Cocos nucifera L. (Arecaceae) leaf was evaluated by acute and sub-chronic toxicity study of the petroleum ether, chloroform and methanol extracts of C. nucifera leaf in Swiss albino mice. In acute toxicity study, each extract up to 2000 mg/kg body weight orally did not produce any toxic effect or death. In sub-chronic toxicity study, the three extracts were administered at the single daily dose of 200 mg/kg body weight orally for 28 consecutive days and at the 29th day, the hematological, histological, serum and hepatic biochemical parameters were evaluated by sacrificing the animals. No mortality was observed during the course of whole study period. No detectable alterations were found in hematological, biochemical and histological parameters in treated groups when compared to vehicle control group after 28 days. The results of the present study therefore indicated that C. nucifera leaf is safe in adult male albino mice demonstrating no noticeable toxicity.



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