TY  - JOUR
T1  - Utilization of the ionotropic gelation technology for the development of gastroretentive floating beads of ondanesteron HCl
A1  - Sura Zuhair Mahmood
A1  - Iman S Jaafar
A1  - Methaq H Sabar
A1  - Nora Zawar Yousif
A1  - Muna Yehia Ismail
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2026
VL  - 16
IS  - 3
DO  - 10.51847/EbRrJv0Ujc
SP  - 24
EP  - 31
N2  - To address the challenges posed by ondansetron’s (Ond) brief biological half-life—which often limits its bioavailability and therapeutic impact—the creation of a gastroretentive controlled-release system represents a highly effective strategic approach. This research details the fabrication of ondansetron-loaded alginate floating beads synthesized via the ionotropic gelation technique. The resultant beads underwent comprehensive characterization, including assessments of drug entrapment efficiency, percentage yield, floating lag time, sustained buoyancy duration, and in vitro dissolution profiles. Furthermore, the optimal formulation was subjected to morphological analysis and an in vivo buoyancy evaluation. Data revealed that the developed beads exhibited a drug content ranging from 91.6 ± 1.2% to 98 ± 1.1% and a process yield between 85% and 97.8%. The delivery system demonstrated a floating lag time of 2–30 minutes, sustained in vitro buoyancy exceeding 24 hours, and cumulative drug release profiles spanning 75% ± 0.3% to 100% ± 0.36%. Additionally, F2, which consists of 1% Na alg, 0.5% HPMCK4M, 1% CaCO3, and 2% CaCl2, was selected as an optimum formula with an in vivo buoyant time of > 6 hrs. In conclusion, Ond alginate-based beads could be considered as promising strategy to decrease dosing frequency, improve the pharmacological activity, and enhance patient compliance‎.
UR  - https://japer.in/article/utilization-of-the-ionotropic-gelation-technology-for-the-development-of-gastroretentive-floating-be-nup33aiwsl9x5uk
ER  -