TY - JOUR T1 - Using oral Rifampin to treat acute central serous Chorioretinopathy: a randomized placebo-controlled clinical trial A1 - Yousef Alizadeh A1 - Mitra Akbari A1 - Soheil Soltanipour A1 - Reza Soltani Moghadam A1 - Abdolreza Medghalchi A1 - Maryam Dourandeesh A1 - Halleh Alizadeh JF - Journal of Advanced Pharmacy Education and Research JO - J Adv Pharm Educ Res SN - 2249-3379 Y1 - 2022 VL - 12 IS - 2 DO - 10.51847/dpPZJj2dvd SP - 11 EP - 18 N2 - This study investigated the possible therapeutic effects of oral rifampin on patients with acute Central Serous Chorioretinopathy (CSC). This clinical trial was a randomized placebo-controlled, double-masked research involving 30 patients with acute CSC. The patients were randomly assigned into two groups, one receiving 600 mg of oral rifampin once a day for a month and another being the matched placebo group. The Best Corrected Visual Acuity (BCVA), the subretinal fluid height at the posterior pole of the eye determined using spectral-domain optical coherence tomography (SD- OCT), and serum cortisol levels were assessed at baseline and an additional three months. The main outcome measures were the BCVA and subretinal fluid height and the secondary outcome measure was the serum cortisol level that was compared between groups. At all follow-up times, significant improvements in BCVA and subretinal fluid resolution were found in both groups, but the differences between them were not statistically significant (P > 0.05). At baseline, the groups did not statistically differ in terms of mean 8 A.M. serum cortisol (C8AM) (P = 0.81). Month 1, however, registered a significant difference in mean C8AM between the groups (P = 0.03). At the end of the second month, this difference reverted to statistical nonsignificance (P = 0.06). The results suggested that the month-long treatment with oral rifampin exerted no beneficial effects on VA and subretinal fluid resolution in acute CSC patients. Such treatment, however, reduced the endogenous steroids of the oral rifampin group‎. UR - https://japer.in/article/using-oral-rifampin-to-treat-acute-central-serous-chorioretinopathy-a-randomized-placebo-controlled-vqakggdhbhgpvcn ER -