TY  - JOUR
T1  - The hypoglycemic effect of purple sweet potato leaf fractions in diabetic rats
A1  - Indah Solihah
A1  - Herlina Herlina
A1  - Elisa Munirah
A1  - Hesty Haryanti
A1  - Mustika Amalia
A1  - Riana Sari Puspita Rasyid
A1  - Tri Suciati
A1  - Fatma Fatma
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2023
VL  - 13
IS  - 3
DO  - 10.51847/rQSvc5gZwg
SP  - 64
EP  - 72
N2  - There is considerable interest in herbal medicine in developing antidiabetic alternative therapy based on plant-derived compounds that would reduce oral hypoglycemic agent-related adverse effects. Ipomoea batatas L. leaf has been reported as rich in phenolic compounds that can reduce the hyperglycemic condition. Research on the hypoglycemic effect of I. batatas L. leaf fraction in alloxan-induced diabetic rats has been conducted. Fractionation methods included gradual maceration with n-hexane, ethyl acetate, and ethanol. The diabetic condition was used alloxan intraperitoneally in rats until blood glucose levels reached > 200mg/dL. Rats were divided into 12 groups that are normal control, diabetic control, insulin treatment, n-hexane fraction (HF), ethyl acetate fraction (EAF), and ethanol fraction (EF) with doses of 50, 100, and 200 mg/kg BW, respectively. Blood glucose level and pancreatic homogenate MDA level were evaluated spectrophotometrically. Histopathology of pancreatic tissues was performed using hematoxylin-eosin stain. According to the findings of this investigation, the decrease in blood glucose level and pancreatic homogenate MDA level of each fraction increased with increasing dosage. The best result was shown:  the ethanolic fraction with a dose of 200 mg/kg BW has not significantly different (p>0.05) from the insulin treatment group in decreasing blood glucose levels and pancreatic homogenate MDA levels. The histopathological observation results showed the dose of 200mg/kg BW of an ethanolic fraction of I. batatas L. leaf had the best improvement pancreatic tissues‎.
UR  - https://japer.in/article/the-hypoglycemic-effect-of-purple-sweet-potato-leaf-fractions-in-diabetic-rats-hxhmjuasszec4pj
ER  -