%0 Journal Article
%T The effect of formulation and process variables on prepared etoricoxib ‎Nanosponges
%A Ahmed Hamed Salman
%A Fatima Jalal Al-Gawhari
%A Khalid Kadima Al-kinani
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2021
%V 11
%N 2
%R 10.51847/Q0QRKUV2kQ
%P 82-87
%X To assess the improvement in solubility and drug release using Nanosponges (NS) deliver system. ETX loaded NSs (ETX-NS) were prepared using the emulsion solvent diffusion ‎method. The ratio of drug: polymer (1:0.25,1:1.5: 1:2 and 1:3) for formulas F1, F2, F3, and ‎F4 respectively, the type and quantity of organic solvent used in the preparation, stirring ‎rate, and sonication effects on the solubility, particle size, and entrapment efficiency and ‎entrapment efficiency of prepared NS were investigated and evaluated.

The solubility of ETX was enhanced when formulated as EXT-Ns. The increase in ‎EC proportion in EXT: EC ratio caused a decrease in solubility of prepared EXT-NS ‎‎(p
%U https://japer.in/article/the-effect-of-formulation-and-process-variables-on-prepared-etoricoxib-nanosponges-gyljur8ieoukddk