TY  - JOUR
T1  - The anticancer, antimalarial, and antibacterial activities of moracalkon a isolated from Artocarpus kemando Miq ‎
A1  - Tati Suhartati
A1  - Nurul Fatimah
A1  - Yandri Yandri
A1  - Rahmat Kurniawan
A1  - Syaiful Bahri
A1  - Sutopo Hadi
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2021
VL  - 11
IS  - 4
DO  - 10.51847/9NHxpCqzUD
SP  - 105
EP  - 110
N2  - Artocarpus kemando Miq. (pudau) is a species of plant from the genus Artocarpus, family Moraceae. Some compounds have previously been isolated from the genus Artocarpus and they showed some bioactivities as antimicrobial, anticancer, antifungal, antiplatelet, anti-inflammatory, antioxidant, antidiabetic and cytotoxic properties. This study aims to isolate and characterize the flavonoid compounds in the root wood of the pudau plant (A. kemando Miq.) which was obtained from Karang Anyar, Klaten, Penengahan, South Lampung, Indonesia. A chalcone compound namely moracalkon A (1) is succesfullyisolated from the root wood of the pudau plant, A. kemando Miq.. Compound 1 was obtained as a yellow solid with a melting point range of 122-125oC. It was well characterized with spectroscopy techniques of UV-Vis, IR, and NMR, and its anticancer activity was tested using murine leukemia cells P-388 and IC50 value was 1.54 g/mL. The antimalarial activity test against Plasmodium falciparum gave IC50 value of 0.08 g/mL and it is categorized as a very active. Furthermore, the antibacterial activity test towards Bacillus subtilis and Escherichia coli showed that compound 1 was strong‎.
UR  - https://japer.in/article/the-anticancer-antimalarial-and-antibacterial-activities-of-moracalkon-a-isolated-from-artocarpus-vrrfrllk66zulpu
ER  -