TY  - JOUR
T1  - Specific changes in intestinal microbiota in various forms of autoimmune arthritis: from pathogenesis to therapy
A1  - Milena Muratovna Attoeva
A1  - Imamali Ilkham-ogly Namazov
A1  - Anzhelika Vladimirovna Kochetkova
A1  - Dinar Magаmedovich Mamedov
A1  - Romazan Andreevich Narunbaev
A1  - Inga Viktorovna Mikhaylova
A1  - Grigoriy Sergeevich Evdokimov
A1  - Aleksander Dmitrievich Palik
A1  - Ksenia Alekseevna Palik
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2025
VL  - 15
IS  - 2
DO  - 10.51847/wvpPpfMkBK
SP  - 180
EP  - 186
N2  - This study investigates the role of the intestinal microbiome in the development of autoimmune arthritides, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). A comparative analysis of gut microbiota composition was performed in 120 patients with various forms of arthritis and 40 healthy volunteers. Using 16S rRNA gene sequencing, disease-specific alterations were identified: a significant increase in Prevotella copri up to 18.3% in RA, predominance of Bacteroides vulgatus (12.6%) in PsA, and elevated levels of Klebsiella pneumoniae (9.8%) in AS. Strong correlations were established between microbiome changes and clinical disease activity parameters. The highest correlation was observed between Prevotella copri levels and anticitrullinated peptide antibody titers (r = 0.62) in RA patients. The therapeutic part of the study demonstrated the efficacy of targeted microbiome correction using specific probiotic strains, resulting in a 1.8–2.1-point reduction in disease activity according to standard assessment indices. These results support the development of innovative diagnostic and therapeutic strategies based on microbiota modification and validate the critical role of the intestinal microbiome in the pathophysiology of autoimmune arthritides. The study significantly contributes to understanding the mechanisms of autoimmune joint diseases and opens new avenues for personalized therapy‎.
UR  - https://japer.in/article/specific-changes-in-intestinal-microbiota-in-various-forms-of-autoimmune-arthritis-from-pathogenesi-90qngaf3wtx6u7o
ER  -