%0 Journal Article %T Semangat: mobile application to improve medication adherence in people living with human immunodeficiency virus in Indonesia %A Hesty Utami Ramadaniati %A Nurita Andayani %A Agung Saputra %A Rasta Naya Pratita %J Journal of Advanced Pharmacy Education and Research %@ 2249-3379 %D 2026 %V 16 %N 1 %R 10.51847/O7DQ8smBkb %P 51-62 %X This study evaluated the effectiveness of the Semangat application in improving antiretroviral treatment (ART) adherence, eHealth literacy (EHL), and human immunodeficiency virus (HIV)-related knowledge among people living with HIV in Indonesia. A quasi-experimental study was conducted among 494 PLWH in 20 primary health centers in Jakarta, equally assigned to an intervention group (IG) and a control group (CG). The IG used the Semangat app for 4 weeks, while the CG received standard care. Outcomes were assessed before and after the intervention using self-administered questionnaires. Baseline characteristics and outcomes were comparable. After the intervention, high adherence increased to 70% in the IG, compared with just over 50% in the CG (p < 0.001). EHL improved markedly in the IG (22.77 to 24.79), with 61.1% achieving good EHL, compared with 30.8% in the CG. HIV knowledge gains were also significantly higher in the IG (p < 0.001). Nearly half rated the app’s usability as good/very good, and 60% were satisfied. In conclusion, Semangat improves ART adherence, EHL, and HIV knowledge, supporting its value as a complement to standard HIV care. %U https://japer.in/article/semangat-mobile-application-to-improve-medication-adherence-in-people-living-with-human-immunodefic-s802ilr2zkhrq7x