TY  - JOUR
T1  - Review of interleukin-6 polymorphisms in rheumatoid arthritis: a genetic implications
A1  - Dhulfiqar Nidhal Alhilali
A1  - Samer Imad Mohammed
A1  - Faiq Isho Gorial
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2025
VL  - 15
IS  - 1
DO  - 10.51847/bxjUqUoEla
SP  - 69
EP  - 77
N2  - The objective review is to inspect the involvement of Interleukin-6 (IL-6) in rheumatoid arthritis (RA) and to highlight the role of IL-6 and its variants in the pathogenesis of RA and response to anti-IL-6 agents. Several genetic and environmental risk factors and infectious agents contributed to the development of RA. Interleukin-6 is engaged in self-targeted immunity by modifying the equilibrium between T regulatory (T-reg) and T helper-17 (Th-17) cells. The evidences reported that IL-6 participated in RA pathogenies including synovitis, angiogenesis, joint damage, and dislocations of bone. IL-6 induces peripheral and central pain sensitization that provokes chronic pain development. Many IL-6 loci contribute to the risk of RA development. Several IL-6 gene variants were studied, which included; -174, -572, -597, and -622 in the 5-flanking region (Promotor). The current data demonstrates the significant role of IL-6 promoter Single Nucleotide Polymorphisms (SNPs), particularly G (-174) C, in the susceptibility and pathogenesis of RA. The C allele linked with the risk, the genotypic and allelic frequencies were higher in Asian and Indian RA patients. Elevated serum IL-6 levels are observed in mutant homozygote CC carriers at the -174 locus, which could explain the impact of this SNP on RA. It seems that age, ethnicity, geographic region, and lifestyle impact the effect of the IL-6 variant in RA. In conclusion; because IL-6 plays a central role in the pathogenesis of RA and its symptoms, it can be speculated that IL-6 promoter SNP (rs1800795) could be a risk agent for RA‎.
UR  - https://japer.in/article/review-of-interleukin-6-polymorphisms-in-rheumatoid-arthritis-a-genetic-implications-ysj3nafvcc92oua
ER  -