%0 Journal Article
%T Relationship Interleukin-8 levels, Malassezia, and sebum fatty acids in dandruff severity
%A Yosse Rizal
%A Nuzulia Irawati
%A Irma D. Rosyanto
%A Netti Suharti
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2025
%V 15
%N 1
%R 10.51847/TdgJvVOwMq
%P 54-59
%X Dandruff is one of the skin diseases that cause problems for patients with complaints of itching. Apart from feeling itchy, it also causes discomfort for patients. This study aims to examine Malassezia species in patients with dandruff by PCR-RT. This is a cross-sectional observational study with a sample size of 60 dandruff patients. Patients were divided into mild/moderate and severe severity based on Severity Dandruff Score. Malassezia species examination was performed by real-time polymerase chain reaction sequencing. Lipid types were determined by gas chromatography-mass spectrometry. IL-8 levels were examined using the Elisa method. The results showed 26 patients with mild-moderate dandruff and 34 with severe dandruff. M.restricta topped the list with 73.3%, followed by M.globosa (23.3%). The most common sebaceous lipid type was hexanediol acid (41.6%), followed by octadecanoic acid (31.7%). IL-8 levels were associated with the severity of dandruff, where in mild-moderate degree, there was an association of p=0.03, while in severe degree, there was a highly relevant association (p=0.00001). This study shows that elevated IL-8 levels are associated with the severity of dandruff. M.restricta is the most common cause of dandruff, while hexanediolic acid is the most common fatty acid that causes dandruff‎.
%U https://japer.in/article/relationship-interleukin-8-levels-malassezia-and-sebum-fatty-acids-in-dandruff-severity-m2inbfqbxv5est0