%0 Journal Article
%T Preparation and in vitro evaluation of topical gel of 5-fluorouracil ‎
%A Zainab Ahmed Sadeq
%A Mais Fadhel Mohammed
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2021
%V 11
%N 4
%R 10.51847/ycPsBAy4RG
%P 80-85
%X Topical drug administration through the skin can be defined ‎as the application of drug contains formulation directly to the skin for prophylactic, protective, ‎or therapeutic purposes. 5-Fluorouracil is an antineoplastic agent used for the treatment of skin diseases such as ‎actinic keratosis. The aim of this work was development a gel formulation of 5-FU using ‎NaCMC and PVA as a gelling agent. Six formulations (F1-F6) were prepared using different concentrations of NaCMC and ‎PVA as a gelling agent, glycerin as a humectant, and methyl hydroxyl benzoate  ‎preservative. The effect of gelling agent type and concentration on the extrudability, ‎spreadability, rheology, and in vitro drug release was investigated. ‎All the prepared gel exhibited acceptable physical properties such as homogeneity, ‎clarity and consistency, pH value, extrudability and, spreadability. The best formulation F1 prepared by using 4% NaCMC as a gelling agent,5% glycerin as a humectant, and 0.2% methyl hydroxyl benzoate as a preservative with pH value 6.38±0.04, ‎drug content 97.2±0.2, extrusion time 12±0.5sec with highest drug release 98.12% through ‎‎3h‎.
%U https://japer.in/article/preparation-and-in-vitro-evaluation-of-topical-gel-of-5-fluorouracil-noepxwp0hnt5xv2