TY  - JOUR
T1  - Pharmacokinetics of Fluconazole tablets administered to healthy subjects
A1  - Afaq Mahde Ammoo
A1  - Duaa Jaafar Jaber Al-Tamimi
A1  - Mustafa Ihssan Abbas Al-Mahroos
A1  - Mariam Jaafar Jaber Al-Tamimi
A1  - Jaafar Jaber Ibraheem
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2021
VL  - 11
IS  - 2
DO  - 10.51847/UR4Sj4hR0i
SP  - 92
EP  - 99
N2  - Fluconazole is an antifungal agent used for treating infections caused by different sorts of fungus and yeasts. Despite the wide usage of fluconazole, up to date, no information is available in the literature concerning the pharmacokinetic characteristics of fluconazole tablets administered to the Arabic population. Since the therapeutic doses of the drug range from 50-400 mg, therefore, the pharmacokinetics of fluconazole 200 mg tablet was investigated in 35 Arabic adult healthy fasting men using plasma concentrations obtained from each one. After overnight fasting of 12 hours, a single dose of the drug was administered and blood samples were withdrawn from each individual before drug intake, and then 17 serial blood samples were obtained for up to 120 hours after drug intake. The current research introduced the primary and the secondary pharmacokinetic parameters of fluconazole 200 mg tablets including Cmax, Tmax, AUC0–t, AUC0–∞, Kelimination (lz), Thalf, MRT, Cl, and Vd which were measured by non-compartmental analysis of the concentrations versus time data of each individual. Moreover, it was found that fluconazole 200 mg tablet was well tolerated by all individuals and no incidence of serious adverse effects was observed‎.
UR  - https://japer.in/article/pharmacokinetics-of-fluconazole-tablets-administered-to-healthy-subjects-gq5rs8mo7bhjsyy
ER  -