TY  - JOUR
T1  - Pattern and profile of different thyroid dysfunctions in Down Syndrome
A1  - Nada Tareq Alshehhi
A1  - Aesha Yousef Alnuaimi
A1  - Taraf Karim Sahib
A1  - Khalid Adel Omar Bazar
A1  - Subhranshu Sekhar Kar
A1  - Rajani Dube
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2025
VL  - 15
IS  - 3
DO  - 10.51847/ef5T0EGvUX
SP  - 1
EP  - 7
N2  - Thyroid disorders are one of the preventable causes of abnormal neurodevelopment in children. Congenital thyroid abnormalities are commonly observed in children with Down syndrome (DS), with previous studies indicating a higher incidence of conditions such as congenital hypothyroidism, subclinical hypothyroidism, and hyperthyroidism. Early detection and treatment are crucial, to prevent permanent neurodevelopmental impairments and other health issues. This retrospective study aimed to assess the prevalence and types of thyroid dysfunction in children with DS at the government Paediatrics hospital in Ras Al Khaimah, between January 2019 and July 2023. Ethical approval was granted by the University and the Ministry of Health Research Ethics Committee, and data were gathered from clinical records using a pre-designed format. Statistical analysis was performed using SPSS version 28, with descriptive statistics and two-sample t-tests to examine gender differences (p < 0.05) considered significant. The study included 31 genetically confirmed DS cases, with 61.3% male (19 cases) and 38.7% female (12 cases). The most prevalent thyroid dysfunction was congenital hypothyroidism (CH), found in 54.8% of the cases, followed by subclinical hypothyroidism in 38.7%, and hyperthyroidism in 6.4%. The most common etiology of CH was thyroid hypoplasia (71%), followed by thyroid ectopia (21%), athyreosis (5%), and partial agenesis (3%) in patients with DS. The results indicate that thyroid dysfunction is a significant concern in children with DS. The findings emphasize the need for routine screening for thyroid abnormalities as recommended by the American Academy of Pediatrics to ensure timely diagnosis and prevent complications associated with untreated thyroid abnormalities in this population.
UR  - https://japer.in/article/pattern-and-profile-of-different-thyroid-dysfunctions-in-down-syndrome-9ap32g995pvn2bx
ER  -