%0 Journal Article
%T Improving the dissolution rate of cilnidipine via nano-micellar formulation aided with In-vitro characterization and Ex-vivo permeation
%A Manar Adnan Tamer
%A Maha Mahdi Ali
%A Ishraq K. Abbas
%A Mowafaq M. Ghareeb
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2025
%V 15
%N 4
%R 10.51847/1G3ULXpAon
%P 75-83
%X The goal of this study is to improve the oral bioavailability of Clindipine (CLD) by converting it into a nano-micellar (NM) dosage form, which will improve its dissolving rate. Nanocarriers such as Soluplus (SLP), D-α-tocopherol polyethylene glycol 1000 succinate (TPGS), Poloxamer (POL 188), and Tween-80 were used to prepare CLD as nano-micellar dispersion (CLD-NM) with one polymer in 1:2, 1:4, 1:6, and 1:8 ratios or with a polymer combination in 1:4:1 and 1:4:2 ratios using the thin film hydration method. Thirteen formulas were produced and principally tested for their physical stability. They were then tested for particle size (P size), polydispersity (PDI), entrapment efficiency (EE%), and drug loading (DL%), followed by in vitro and ex vivo tests. Only the selected formula was studied in terms of morphology and compatibility. The drug-loaded nano-micelles of the selected formula coded (F12) were analyzed and determined to be: micelle size (43.76±0.3 nm), PDI (0.2899±0.02), EE% (99.99±0.2%), and DL% (16.7±0.1%). An in vitro release research was carried out, and the results revealed that the chosen formula CLD released the entire amount of medication in 45 minutes, as opposed to just 19% for the pure drug.  Ex vivo experiments revealed that F12 increased flow by approximately 4.2 times as compared to CLD suspensions.
%U https://japer.in/article/improving-the-dissolution-rate-of-cilnidipine-via-nano-micellar-formulation-aided-with-in-vitro-char-avhdnvkbv0kvrqb