TY  - JOUR
T1  - Impact of preparation techniques on formulation and characterization of captopril effervescent granules
A1  - Ishraq K. Abbas
A1  - Marwah M. Hareeja
A1  - Saba Abdulhadi Jaber
A1  - Adnan Burhan Qader
A1  - Raffah Khamis Mahal
A1  - Omar Saeb Salih
A1  - Ahmed Abbas Hussein
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2025
VL  - 15
IS  - 2
DO  - 10.51847/8aO2P1Lp5P
SP  - 51
EP  - 56
N2  - Captopril aqueous solution prepared using the drug as a powder dissolved in water was stable only for approximately twenty-seven days. The present work aimed to prepare captopril as stable dry solid effervescent granules that form a suitable swallowing aqueous liquid dosage for pediatrics. Six formulas were prepared, by wet, and; fusion methods, using different ratios of citric acid and tartaric acid with potassium bicarbonate as the effervescent base. The granules evaluation was done concerning their flowability, tapped density, bulk density, and the angle of repose, as well as pH, Carr’s; Index, effervescent time, particle size, drug content, and the dissolution study, all were performed in vitro. F2, prepared by wet granulation method at a ratio of 1:2:4.8 citric acid, tartaric; acid, with; potassium bicarbonate respectively was chosen as the selected formula as it exerts an accepted flow property, good distribution, and drug content of 97.5%. Fast effervescence time with 100% releases within 48.44 sec, and 2 min respectively. Captopril was successfully prepared as an effervescent granule, especially using the wet granulation technique‎.
UR  - https://japer.in/article/impact-of-preparation-techniques-on-formulation-and-characterization-of-captopril-effervescent-granu-henjlfrhxp16dm7
ER  -