TY  - JOUR
T1  - Formulation and optimization of clotrimazole nail lacquer as transungual drug delivery system
A1  - Roaa A. Nief
A1  - Ahmed Yousif Fadhel
A1  - Ghufran H. Mahmood
A1  - Ashti MH. Saeed
A1  - Mohammed Layth Hamzah
A1  - Fatimah Waleed Tarkan
A1  - Tabarak Qais Khazal
A1  - Zeena Ali Khalaf
A1  - Dhuha Abdulazeez Shihab
A1  - Hawrah Emad Salamah
A1  - Batool Salah Muhi
A1  - Dhuha Nadhum Maajel
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2026
VL  - 16
IS  - 1
DO  - 10.51847/6aCU1pFl8L
SP  - 73
EP  - 79
N2  - Clotrimazole nail lacquer was created using this research, which also included the incorporation of two different kinds of polymers. (Eudragit RL 100 and ethyl cellulose) in various concentrations, as well as castor oil as a plasticizer, salicylic acid as a keratolytic agent, and N-acetylcysteine as a penetration enhancer. The objective was to optimize the selection of polymers and their concentrations to enhance release efficacy based on in vitro permeability experiments, while also ensuring favorable film characteristics, such as flexibility, gloss, adhesive qualities, drying time, non-volatile content, viscosity, and water resistance. Formulation F3 was selected as the superior formula considering several parameters, including excellent flow and gloss, ideal drying time and viscosity, adhesiveness, and penetration tests. Formula After 24 hours, F3, the drug penetration rate, was 78.4%. Based on the outcomes of the earlier tests, the formulated medicated nail lacquers are cost-effective and exhibit superior patient compliance‎.
UR  - https://japer.in/article/formulation-and-optimization-of-clotrimazole-nail-lacquer-as-transungual-drug-delivery-system-hp49l03b4s1afvk
ER  -