TY  - JOUR
T1  - Formulation and in vitro evaluation of medicated chocolate of ondansetron for pediatrics
A1  - Mais Fadhel Mohammed
A1  - Amenah Moustafa Mohammed
A1  - Amani Shakir Hadi
A1  - Fatima Ali Tawfiq
A1  - Zahraa Mohammed Radhi
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2026
VL  - 16
IS  - 2
DO  - 10.51847/wEY3bic8Cc
SP  - 184
EP  - 191
N2  - Managing oral drug administration in pediatrics faces significant compliance challenges due to the bitter taste of active pharmaceutical ingredients like ondansetron, which often leads to therapy rejection. This study designed, formulated, and evaluated a palatable, chocolate-based immediate-release oral delivery system to effectively mask drug bitterness and enhance patient adherence. Five distinct formulations (F1–F5) of ondansetron medicated chocolate were prepared by compounding uniform drug amounts (4 mg) with cocoa powder, milk powder, and sucrose syrup into a melted base containing varying concentrations of cocoa butter and lecithin powder. The resulting prepared formulations were thoroughly evaluated for physical appearance, weight variation, hardness, moisture content, disintegration time, and in-vitro drug release profiles. All batches exhibited a uniform dark brown color, smooth texture, pleasant odor, and zero blooming. The moisture content remained exceptionally low (
UR  - https://japer.in/article/formulation-and-in-vitro-evaluation-of-medicated-chocolate-of-ondansetron-for-pediatrics-xgbkd2d3mzpryeq
ER  -