TY  - JOUR
T1  - Factors controlling development of benazepril mouth dissolving drug delivery system
A1  - Methaq Hamad Sabar
A1  - Iman Sabah Jaafar
A1  - Ameerah Abdulelah Radhi
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2022
VL  - 12
IS  - 4
DO  - 10.51847/JQC55C3x8x
SP  - 12
EP  - 18
N2  - The objective of this trial was to design, formulate and in vitro evaluate benazepril hydrochloride (BNZH) (an anti-hypersensitive drug), fast dissolving oral film to deliver rapid onset of action as well as maximum therapeutic effectiveness through the simplicity of swallowing mainly for geriatrics who suffer from dysphagia. Different films were prepared via a solvent casting method sodium carboxymethyl cellulose (SCMC), hydroxyl propyl methyl cellulose (HPMC100), HPMC E15, and polyvinyl alcohol (PVA) as film developing polymers. Glycerin and propylene glycol (PG) was used as a plasticizer to improve the polymer film-forming characteristics. Tween 80 was used as a surfactant and citric acid (CA) as a saliva stimulating agent. Prepared films were then examined for both physical and mechanical properties including weight dissimilarity, thickness, surface pH, drug content as well as folding endurance. Both in vitro disintegration time in addition to drug release profile were also assessed for each formulation. According to the outcomes of this study, it is clear that F5 which consisted of 40% SCMC as a main film-forming polymer and 20% glycerin as a plasticizer, runs satisfactory physicochemical characteristics, in vitro DT (20 sec), nevertheless adequate release parameters as 99.8±0.14 released at 2 min and 80% of drug released in less than one minutes‎.
UR  - https://japer.in/article/factors-controlling-development-of-benazepril-mouth-dissolving-drug-delivery-system-124j80vyg9efzsu
ER  -