TY  - JOUR
T1  - Exploring the frontiers of penicillin pharmaceuticals: a comprehensive review of advancements and innovations
A1  - Assyl Boshkayeva
A1  - Abay Massakbayev
A1  - Galiya Sayakova
A1  - Serzhan Mombekov
A1  - Rustam Yussupov
A1  - Tanagul Arystanova
A1  - Aigul Tazhiyeva
A1  - Galiya Ibadullayeva
A1  - Nazym Pushkarskaya
A1  - Meruyert Tleubayeva
A1  - Gulbarshyn Aitzhanova
A1  - Farida Kayupova
A1  - Kaldanay Kozhanova
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2026
VL  - 16
IS  - 1
DO  - 10.51847/2M8kLppG32
SP  - 138
EP  - 148
N2  - Penicillin and its derivatives have remained a cornerstone in combating bacterial infections for decades. However, growing concerns about bacterial resistance and the limitations of conventional penicillin production methods underscore the need for innovative approaches. The aim of this review is to address the challenge of developing penicillin and related compounds by proposing a novel approach to improving the quality of medicines to meet healthcare demand. The discovery and optimization of microbial sources for penicillin production pose potential solutions to the growing demand for novel antibiotics. High-throughput screening techniques, genomics, and bioinformatics tools enable the identification and characterization of novel penicillin-producing microorganisms. The optimization of enzyme production and purification processes further enhances the scalability and cost-effectiveness of penicillin biosynthesis. However, despite significant progress, several gaps persist in large-scale, sustainable penicillin production and effective manufacturing processes. To address these gaps, this review provides a comprehensive overview of recent advancements and emerging trends in the development and manufacturing of penicillin. With an interdisciplinary lens, we point out new approaches, including biocatalysis, green chemistry principles, and advanced processes. Integrating these strategies would develop the next-generation penicillin derivatives with better efficiency, reduced environmental footprint, and enhanced resistance profiles. This extraordinary combination of research identifies current gaps in penicillin drug development and charts a path toward sustainable solutions for future antibiotic needs‎.
UR  - https://japer.in/article/exploring-the-frontiers-of-penicillin-pharmaceuticals-a-comprehensive-review-of-advancements-and-in-coyzg3phceodvcs
ER  -