TY  - JOUR
T1  - Evaluation of genotoxicity and cytotoxicity of silver nanoparticles
A1  - Anastasia Evgenievna Pecherskaya
A1  - Daria Vladimirovna Andreeva
A1  - Kamilla Magomedovna Abdulazizova
A1  - Fariza Magometovna Sampieva
A1  - Madina Beslanovna Albogachieva
A1  - Anna Garikovna Babayan
A1  - Yana Ruslanovna Esenova
A1  - Anastasia Gennadievna Lubentseva
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2023
VL  - 13
IS  - 3
DO  - 10.51847/MAq20NSenF
SP  - 23
EP  - 28
N2  - The toxicological and hygienic assessment of the safety of nanoscale colloidal silver produced on a large scale by the modern nano industry is an important task because of its employment medicine. This work aimed to evaluate the mutagenic and cytotoxic properties of silver nanoparticles stabilized with polyvinylpyrrolidone. Silver nanoparticles stabilized with polyvinylpyrrolidone were synthesized for the experiment. The silver particles had a size of about 300 nm, but some of them turned out to be slightly smaller, about 80 nm. The absorption spectrum of UV/Vis electromagnetic waves displayed an absorption peak of 409 nm, which is typical for silver nanoparticles. The exposure time was 10 minutes. Control cultures were placed in saline without glutamate for 10 minutes. Cultures were then returned to the original nutrient medium and placed in a CO2 incubator for 4.5 hours. The excess of β-galactosidase activity over the control in PVP was 0.9±0.03 and 1.2±0.03, and in AgNPs+PVP – 0.6±0.38 and 0.6±0.12. MCF7-test showed that in the presence of silver nanoparticles, the cells acquired a spherical shape and did not show proliferation. AgNPs+PVP activated cell proliferation, which can enhance the wound healing effect‎.
UR  - https://japer.in/article/evaluation-of-genotoxicity-and-cytotoxicity-of-silver-nanoparticles-mdnr1tpzyex7jov
ER  -