%0 Journal Article
%T Comparison between Gardenia jasminoides J. Ellis and Celosia cristata Linn. against Aggregatibacter actinomycetemcomitans: in vitro study ‎
%A Regina Widjaja
%A Josephine Felicia
%A Calvin Kurnia
%A Dicha Yuliadewi Rahmawati
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2025
%V 15
%N 1
%R 10.51847/tVHfXK7wc3
%P 25-28
%X Aggregatibacter actinomycetemcomitans (Aa) is one of the causes of periodontitis. Although severe periodontitis can be treated locally with chlorhexidine, prolonged usage of the medication can have negative consequences. Consequently, to take over for chlorhexidine, other options are required. The purpose of this study is to determine which plants have a stronger antibacterial effect on Aa as well as if Gardenia jasminoides J. Ellis (GJ) and Celosia cristata Linn. (CC) have any effect at all. GJ flowers (GJF) and CC flowers (CCF) were the materials utilised in this study which, together with a 96% ethanol solvent and the maceration process, is turned into a thick liquid extract. This study employed the microdilution and the agar dilution. Tukey's post-hoc analysis was used for multiple comparisons and one-way analysis of variance was used to examine differences across all data sets. 6.25% GJF extract (GJFE) and 25% CCF extract (CCFE) showed a drastic decrease in optical density, and colony forming units that did not form at all were observed in 12.5% GJFE and 25% CCFE. The antibacterial activity of GJ and CC against Aa is comparable to 2% chlorhexidine gluconate, notwithstanding this fact. With a minimum inhibitory concentration (MIC) of 6.25% (0.527 ± 0.013) and a minimum bactericidal concentration (MBC) of 12.5% (0.00 ± 0.000), GJ was the plant with the superior antibacterial action on Aa‎.
%U https://japer.in/article/comparison-between-gardenia-jasminoides-j-ellis-and-celosia-cristata-linn-against-aggregatibacter-dckzupkeevpziff