%0 Journal Article
%T Breast cancer models in female rat strain Wistar with benzopyrene injection
%A Nike Sari Oktavia
%A Arifa Mustika
%A Afif Nurul Hidayati-
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2025
%V 15
%N 4
%R 10.51847/mY3uYhID08
%P 37-43
%X This study aimed to determine whether female rat strain Wistar with intramammary injection of benzopyrene can form breast cancer, whether there is a correlation between the time of tumor formation and the size of tumor with the category of tumor. This study used 35 female rats Wistar strain, 8-11 weeks. All rats had been intramammary injected with benzopyrene 3-5% at a dose of 50 mg/KgBW in 5 injections every 2 days. Swelling/lumps occur between 4-5 weeks to 17-18 weeks. The tumor was processed for Hematoxylin Eosin (HE) staining, and the results were viewed under a microscope with 400x magnification. There were 48.57% of rats that succeeded in forming tumors, with 34.28% being malignant phyllodes, 2,86% being metaplastic carcinoma, 2.86% being benign phyllodes, 2.86% being mesenchymal, and 5.71% being lymph gland. The results showed that the Spearman correlation between the time of tumor formation and the category of tumor had a value of p = 0.002 (p
%U https://japer.in/article/breast-cancer-models-in-female-rat-strain-wistar-with-benzopyrene-injection-rnptedt9rryesup