%0 Journal Article
%T Bioavailability study of Posaconazole in rats after oral Poloxamer P188 Nano-micelles and oral Posaconazole pure drug
%A Alaa Abdulelah Abdulqader
%A Nawal Ayash Rajab
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2023
%V 13
%N 2
%R 10.51847/Q59uyvRmY3
%P 140-143
%X Posaconazole (POCZ) is a triazole antifungal with poor solubility and low bioavailability, so this work is aimed to compare between bioavailability parameters of pure POCZ and the prepared lyophilized POCZ nano-micelles. In this study, twelve Wistar rats were used with a weight of 200±20g and divided into twice groups (each group with six animals). The dose of 10mg/kg of pure POCZ and POCZ nano-micelles was administered to rats by oral gavage after reconstitution with water. The determination of POCZ in the plasma of rats is done by using (HPLC) after the construction of a spiked calibration curve with plasma and internal standard itraconazole. The bioavailability parameters for pure POCZ and POCZ nano-micelles were determined. The results show that Cmax, Tmax, AUC0-72, and AUC0-∞ were 230±4ng/ml, 8±0.5hr, 8622±127 ng.h/ml,10050±110 ng.h/ml and 2107±7ng, 2±0.2hr, 27261. 2±233ng.h/ml, 30364±205 respectively for pure POCZ suspension and POCZ nano-micelles. The obtained results from this work are that the time Tmax required for maximum concentration Cmax was statistically different from pure POCZ and POCZ nano-micelles (p
%U https://japer.in/article/bioavailability-study-of-posaconazole-in-rats-after-oral-poloxamer-p188-nano-micelles-and-oral-posac-wtygc57mu0r5b1r